San Francisco 49ers at Seattle Seahawks betting tips and NFL predictions: Lively start to Week Six is expected

Where to watch San Francisco 49ers at Seattle Seahawks

Sky Sports NFL & Main Event, 1.15am Thursday night

Best bet

Over 48.5 points
2pts 10-11 Coral, Ladbrokes, Paddy Power

San Francisco 49ers at Seattle Seahawks predictions

NFL Week Six could get off to an entertaining start with the NFC West clash between the San Francisco 49ers and the Seattle Seahawks.

The 49ers remain the favourites to win the NFC again after their Super Bowl appearance last year, but they have lost three of their first five outings this season, so need to raise their game in this key divisional clash.

They are still without star running back Christian McCaffrey, and defensive injuries have been a problem for the 49ers. On top of that this is a tough trip to make on a short turnaround against a division rival also with plenty to prove.

The Seahawks suffered a defensive meltdown on Sunday, giving up 24 first downs and 420 total yards to a Giants team missing their star wide receiver, Malik Nabers. Two of their best defensive linemen remain unavailable and their secondary is also dealing with a number of injuries. 

Seattle's offence should be able to bounce back, though, and in what looks a close contest, the Seahawks could be the pick as home underdogs. Even so, the best bet on the game should be to go over on total points.

Brock Purdy is likely to have plenty of time to find his receivers and the 49ers quarterback can be deadly in that situation, while Jordan Mason is averaging 107.2 rushing yards per game filling in for McCaffrey. 

The San Francisco pass-rush is not the force it was last season due to injuries and while Seattle QB Geno Smith took seven sacks against the Giants he should have more time to find talented receivers DK Metcalf, Tyler Lockett and Jaxon Smith-Njigba this week.

The lowdown

Venue Lumen Field, Seattle, Washington
Surface Artificial
Weather Cloudy, 14C
Vegas line Seahawks +3.5
Points line 48.5

Pickswise is the #1 destination for US sports betting, covering the NFL, NBA, MLB and more in unrivalled detail. 

For all your US sports betting needs, make sure to check out Pickswise, the home of stateside picks, predictions and odds.

Click for free bets and betting offers from the Racing Post

Commercial notice: This article contains affiliate links. Offers are handpicked and come from operators our experts have first-hand experience of. Opening an account via one of these links will earn revenue for the Racing Post, which will be used to continue producing our award-winning coverage of horseracing and sports betting.