LA Rams at San Francisco 49ers betting tips and NFL predictions: 49ers to keep alive playoff hopes

Where to watch LA Rams at San Francisco 49ers

Sky Sports NFL & Sky Sports Main Event, 1.15am Thursday night

LA Rams at San Francisco 49ers best bet

San Francisco -2.5
3pts Evs Coral, Labrokes

LA Rams at San Francisco 49ers predictions

The San Francisco 49ers enhanced their playoff aspirations with a Week 14 victory over the Chicago Bears and they can keep alive their hopes of a repeat Super Bowl appearance when they clash with NFC West rivals Los Angeles Rams on Thursday evening.

The Niners desperately needed to beat the Bears and they came out firing, out-gaining their opponents 309-4 in total first-half yards before cruising to a 38-13 triumph.

At 6-7, there are no easy contests left on their schedule – they face the Dolphins, Lions and Cardinals after this Levi's Stadium clash – and they must finish with four victories to have any shot at another Super Bowl appearance. 

Motivation is sky-high and San Francisco look worthy favourites on a short turnaround, particularly with home-field advantage.

The Rams were equally impressive in their thrilling 44-42 win over the Buffalo Bills and their offence is lethal, although they’ve had their challenges against their divisional rivals.

While LA have won the last two meetings – including in the final week of the 2023 regular season when both backup quarterbacks were in action – the 49ers were successful in nine previous regular-season clashes.

There’s also a chance that San Francisco will get back a few of their stars, including Trent Williams, Nick Bosa and Dre Greenlaw, who would all be significant additions if they are available.

The 49ers will be out to avenge that Week Three loss and can win by at least a field goal.

The lowdown

Venue Levi's Stadium, Santa Clara, California
Surface Grass
Weather Showers, 12C
Vegas line LA Rams +2.5
Points line 49.5

Pickswise is the #1 destination for US sports betting, covering the NFL, NBA, MLB and more in unrivalled detail. 

For all your US sports betting needs, make sure to check out Pickswise, the home of stateside picks, predictions and odds.

Click for free bets and betting offers from the Racing Post

Commercial notice: This article contains affiliate links. Offers are handpicked and come from operators our experts have first-hand experience of. Opening an account via one of these links will earn revenue for the Racing Post, which will be used to continue producing our award-winning coverage of horseracing and sports betting.